Novel agents and use thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) C07K 14/47 (2006.01) C07K 16/22 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2651064

The present invention provides agents for inhibiting the metastasis of cancer cells wherein the agent inhibits the biological activity of hCAP18/LL-37. In a preferred embodiment, the agent alters the transcription, translation and/o binding properties of hCAP18/LL-37. Preferably, the agent is selected from th group consisting of short interfering RNA (siRNA) molecules, antisens oligonucleotides and compounds with binding affmity for hCAP18/LL-37 or it receptor(s). The invention further provides methods for inhibiting the metastasis of cancer cells in a patient, as well as methods and kits for diagnosing cancer.

La présente invention concerne des agents destinés à inhiber les métastases de cellules cancéreuses, lesdits agents inhibant l'activité biologique de hCAP18/LL-37. Dans un mode de réalisation préféré, l'agent modifie la transcription, la traduction et/ou les propriétés de liaison de hCAP18/LL-37. De préférence, l'agent est choisi parmi le groupe constitué par des molécules de petits ARN interférents (ARNsi), des oligonucléotides antisens et des composés dotés d'une affinité de liaison pour hCAP18/LL-37 ou son récepteur (ses récepteurs). L'invention concerne en outre des procédés destinés à inhiber les métastases de cellules cancéreuses chez un patient, aussi bien que des procédés et des trousses permettant de diagnostiquer un cancer.

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