Novel agents for the prevention of leishmaniosis

Details Novel agents for the prevention of leishmaniosis Novel agents for the prevention of leishmaniosis

C - Chemistry, Metallurgy

07

K

C07K 14/44 (2006.01) C12N 1/11 (2006.01) C12N 15/30 (2006.01)

Patent

CA 2546326

The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of Leishmania, said nucleic acids responding to one of the sequences SEQ ID No.1, SEQ ID No.2, SEQ ID No.3, SEQ ID No.4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No.10 et SEQ ID No. 12. The invention can be used for over-expression of the genes of Leishmania coding for an excretion/secretion antigen.

L'invention a pour objet des constructions d'acides nucléiques, caractérisées en ce qu'elles comportent des acides nucléiques isolés en position sens, capables de coder pour une protéine immunogène de formes promastigotes ou de formes amastigotes de Leishmania, lesdits acides nucléiques répondant à l'une des séquences SEQ ID N~1, SEQ ID N~2, SEQ ID N~3, SEQ ID N~4, SEQ ID N~5 et SEQ ID N~11 et codant pour une protéine présentant, respectivement, une séquence SEQ ID N~6, SEQ ID N~7, SEQ ID N~8, SEQ ID N~9, SEQ ID N~10 et SEQ ID N~12. Application pour la surexpression de gènes de Leishmania codant pour un antigène d'excrétion/ sécrétion.

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