Novel alanyl-amino peptidase inhibitors for functionally...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01) A61K 31/4015 (2006.01)

Patent

CA 2542723

The invention relates to medicinally used substances which specifically inhibit peptidases splitting ala-p-nitroanilide. The invention further relates to the use of at least one such substance or at least one pharmaceutical or cosmetic composition containing such a substance for preventing and treating diseases, especially diseases with an overshooting immune response (autoimmune diseases, allergies, and transplant rejections), other chronic inflammatory diseases, neuronal diseases, brain damages, skin diseases (acne and psoriasis, among others), tumor diseases, and special viral infections (including SARS).

La présente invention concerne des substances inhibant spécifiquement des peptidases divisant ala-p-nitroanilide, destinées à une utilisation en médecine. L'invention concerne également l'utilisation d'au moins une telle substance ou d'au moins une composition pharmaceutique ou cosmétique contenant au moins une telle substance, dans la prophylaxie et la thérapie de maladies, notamment de maladies caractérisées par une réponse immunitaire excessive (maladies auto-immunes, allergies et rejets de greffes), d'autres maladies inflammatoires chroniques, de maladies neuronales, de traumatismes cérébraux, de maladies dermatologiques (par ex. l'acné et le psoriasis), de maladies tumorales et d'infections virales spécifiques (par ex. le SRAS).

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