Novel aldolase and production process of substituted...

Details Novel aldolase and production process of substituted... Novel aldolase and production process of substituted...

C - Chemistry, Metallurgy

12

N

C12N 15/60 (2006.01) C12N 9/88 (2006.01) C12P 7/50 (2006.01) C12P 17/10 (2006.01)

Patent

CA 2484871

4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.

Selon l'invention, l'utilisation d'aldolases ayant pour origine des micro-organismes appartenant aux genres <i>Pseudomonas</i>, <i>Erwinia</i>, <i>Flavobacterium</i> et <i>Xanthomonas</i>, permet de synthétiser un acide 4-(indol-3-ylméthyl)-4-hydroxy-2-oxoglutarique, utile en tant qu'intermédiaire dans la synthèse de monatine, à partir d'acide indolépyruvique et d'acide pyruvique (ou d'acide oxaloacétique).

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