C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/08 (2006.01) A61K 31/164 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07C 231/12 (2006.01) C07C 231/18 (2006.01)
Patent
CA 2425923
Compounds of the general formula (I) which are each in the form of a (2R, 3S, 2'S) optical isomer when the bond at the 8-position is double or in the form of (2S, 3R, 2'RS) optical isomers when the bond at the 8-position is single, or their pharmacologically acceptable salts; a process for preparing the same; and use of the same in treatment of circulatory diseases (such as arteriosclerosis and cardiopathy), cancer, rheumatism, diabetic retinopathy, and respiratory diseases. In said formula, n is an integer of 1 to 11; and 1 is an integer of 1 to 16.
L'invention concerne des composés correspondant à la formule générale (I), lesquels sont chacun sous la forme d'un isomère optique (2R, 3S, 2'S) lorsque la liaison au niveau de la position 8 est double, ou sous la forme d'isomères optiques (2S, 3R, 2'RS) lorsque la liaison au niveau de cette position 8 est simple. L'invention concerne également des sels de ces composés, acceptables sur le plan pharmacologique, un procédé de préparation de ces composés et sels, ainsi que l'utilisation de ceux-ci dans le traitement de maladies circulatoires (telles que l'artériosclérose et les cardiopathies), du cancer, des rhumatismes, de la rétinopathie diabétique et des maladies respiratoires. Dans cette formule(I), n représente un nombre entier compris entre 1 et 11, et l représente un nombre entier compris entre 1 et 16.
Mori Kenji
Nishikawa Masazumi
Tamai Tadakazu
Maruha Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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