Novel alkyl-containing 5-acylindolinones, their preparation...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/34 (2006.01) A61K 31/501 (2006.01) A61P 25/28 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2559139

The invention relates to alkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claim 1, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).

La présente invention concerne des 5-acylindolinones à teneur en alkyle de formule générale (I) dans laquelle R1 à R3 sont tels que définis dans la revendication 1, leurs tautomères, leurs énantiomères, leurs diastéréomères, leurs mélanges et leurs sels, qui ont des propriétés pharmacologiques intéressantes, notamment une action d'inhibition sur des protéine kinases, en particulier sur l'activité de la glycogène-synthase-kinase (GSK-3).

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