C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/30 (2006.01) A61K 31/4375 (2006.01) A61P 3/04 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/42 (2006.01) C07D 213/48 (2006.01) C07D 213/53 (2006.01) C07D 213/55 (2006.01) C07D 213/56 (2006.01) C07D 213/57 (2006.01) C07D 213/61 (2006.01) C07D 213/64 (2006.01) C07D 213/65 (2006.01) C07D 213/73 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 213/85 (2006.01) C07D 215/12 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 333/16 (2006.01) C07D 40
Patent
CA 2504160
The present invention relates to alkyne compounds of general formula I (see formula I) wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
Composés alkine de formule générale (I) dans laquelle les groupes et restes A, B, W, X, Y, Z, R?1¿ et R?2¿ possèdent la signification figurant dans la revendication 1. La présente invention concerne en outre des médicaments contenant au moins une alkine selon la présente invention. En raison de leur activité antagoniste contre le récepteur MCH, les médicaments selon la présente invention sont adaptés pour le traitement de troubles métaboliques et / ou de l'alimentation, en particulier de l'obésité, de la boulimie, de l'anorexie, de l'hyperphagie et du diabète.
Arndt Kirsten
Lehmann-Lintz Thorsten
Lenter Martin
Lotz Ralf Richard Hermann
Lustenberger Philipp
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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