Novel .alpha.-amino-n-(diaminophosphinyl)lactam derivatives

Details Novel .alpha.-amino-n-(diaminophosphinyl)lactam derivatives Novel .alpha.-amino-n-(diaminophosphinyl)lactam derivatives

C - Chemistry, Metallurgy

07

F

C07F 9/59 (2006.01) A61K 31/675 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 7/00 (2006.01) A61P 7/06 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 31/18 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07F 9/553 (2006.01) C07F 9/568 (2006.01) C07F 9/572 (2006.01)

Patent

CA 2479898

A novel .alpha.-amino-N-(diaminophosphinyl)lactam derivative represented by the general formula (I) [wherein, for example, A represents hydrogen or a substituent such as lower alkyl; W, X, Y, and Z each independently represents hydrogen or a substituent such as lower alkyl, aryl, arylacyl, or arylaminocarbonyl; and Q represents -(CH2)n- (n is 0 to 3)] or a salt of the derivative; and a therapeutic agent and preventive for marrow inhibition, a therapeutic agent for infectious diseases, a leukocyte enhancer, and a dipeptidyl peptidase IV inhibitor which each contains the derivative or salt as an active ingredient.

La présente invention concerne un nouveau dérivé d'.alpha.-amino-N-(diaminophosphinyl)lactame représenté par la formule générale (I) ou l'un de ses sels. Dans cette formule générale (I), notamment, A est hydrogène ou un substituant tel qu'un alkyle inférieur; W, W, Y et Z sont chacun indépendamment hydrogène ou un substituant tel qu'un alkyle inférieur, un aryle, un arylacyle ou un arylaminocarbonyle; et Q est CH¿2?)¿n?-, n valant de 0 à 3. L'invention concerne également un agent thérapeutique ou prophylactique de l'inhibition médulaire, un agent thérapeutique de maladies infectieuses, un activateur leucocytaire, et un inhibiteur de la peptidase IV des dipeptidyles, le principe actif de chacun de ces agents étant le dérivé de l'invention ou l'un de ses sels.

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