Novel amide compounds and drugs containing the same

C - Chemistry – Metallurgy – 07 – D

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C07D 403/12 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2303781

Novel compounds having an ACAT inhibitory effect. Specifically, compounds represented by general formula (I) or salts or solvates thereof and medicinal compositions containing at least one of these compounds, wherein (A) represents a divalent residue of optionally substituted benzene, pyridine, cyclo-hexane or naphthalene, or (B); HET represents an optionally substituted, monocylcic, polycyclic or fused 5- to 8-membered heterocycle; X represents -NH- , oxygen or sulfur; Y represents -NR4-, oxygen, sulfur, sulfoxide or sulfone; Z represents a single bond or -NR5- (R4 and R5 representing each a specific group); and n is an integer of 1 to 15.

On décrit de nouveaux composés ayant un effet inhibiteur ACAT. D'une manière plus spécifique, on décrit des composés représentés par la formule (I) ou bien des sels ou des solvates de ces derniers ainsi que des compositions médicamenteuses contenant au moins un de ces composés, dans laquelle (A) représente un reste bivalent de benzène, pyridine, cyclohexane ou naphtalène facultativement substitué, ou (B); HET représente un hétérocycle de 5 à 8 éléments monocyclique, polycyclique ou fusionné, facultativement substitué; X représente -NH-, oxygène ou soufre; Y représente -NR4-, oxygène, soufre, sulfoxyde ou sulfone; Z représente une liaison simple ou -NR5- (R4 et R5 représentant chacun un groupe spécifique); et n représente un entier compris entre 1 et 15.

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