C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01)
Patent
CA 2687180
The present invention provides a novel amide derivative and a pharmaceutically acceptable salt thereof which selectively and effectively inhibits the growth of cancer cells induced by the overexpression of an epidermal growth factor receptor and also prevents the development of drug resistance caused by the mutation of EGFR tyrosine kinase, and a pharmaceutical composition comprising same as an active ingredient.
La présente invention concerne un nouveau dérivé d'amide, et son sel pharmaceutiquement acceptable, qui peut inhiber sélectivement et efficacement la croissance de cellules cancéreuses induites par la surexpression d'un récepteur du facteur de croissance épidermique, mais aussi empêcher le développement de la résistance au médicament causée par la mutation de la tyrosine kinase EGFR. L'invention concerne également une composition pharmaceutique comprenant ce dérivé coomme principe actif.
Ahn Young-Gil
Bang Keukchan
Cha Mi Young
Chae Yun Jung
Choi Bo Im
Cassan Maclean
Hanmi Holdings Co. Ltd.
Hanmi Pharm. Co. Ltd.
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