C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/30 (2006.01) A61K 31/137 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/428 (2006.01) A61K 31/44 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 27/14 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07C 233/78 (2006.0
Patent
CA 2456096
It is intended to provide a novel low-molecular weight amine derivative having a human .beta.-tryptase inhibitory activity which shows a high absorbability, a low toxicity and an extremely high selectivity, pharmaceutically acceptable salts thereof and drugs containing the same as the active ingredient. These drugs are efficacious as preventives/remedies for diseases in the onset and progress of which .beta.-tryptase seemingly participates, for example, respiratory diseases, allergic diseases, inflammatory intestinal diseases, hyperprolliferative skin diseases, vascular edema and rheumatoid arthritis.
L'invention concerne un nouveau dérivé aminé de faible poids moléculaire, présentant une activité inhibant la .beta.-tryptase humaine, une haute absorbabilité, une faible toxicité et une sélectivité extrêmement élevée, des sels pharmaceutiquement acceptables dudit dérivé, et des médicaments contenant ce dérivé en tant que principe actif. Ces médicaments sont efficaces en tant que médicaments préventifs/remèdes pour des maladies au début desquelles, et au cours desquelles, la .beta.-tryptase semble jouer un rôle, par exemple, des maladies respiratoires, des maladies allergiques, des maladies intestinales inflammatoires, des maladies de peau hyperprolifératives, des oedèmes vasculaires et l'arthrite rhumatismale.
Kato Yutaka
Manabe Tadashi
Miyazaki Yutaka
Okamoto Atsushi
Shimada Hiroyasu
Mochida Pharmaceutical Co. Ltd.
Smart & Biggar
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