Novel amino acid derivatives

Details Novel amino acid derivatives Novel amino acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 235/12 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 38/05 (2006.01) C07C 233/47 (2006.01) C07C 237/12 (2006.01) C07C 323/41 (2006.01) C07C 323/59 (2006.01) C07D 209/18 (2006.01) C07D 233/26 (2006.01) C07D 277/30 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2125679

A novel amino acid derivative represented by the general formula (T) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. (see formula I) wherein y is 0 or 1; R1 represents an unsubstituted C1-C8 alkyl group or others; R2 represents a hydrogen atom, a C1-C5 alkyl group or others; R3 represents a hydrogen atom, a C1-C8 alkyl group or others; R4 represents a hydrogen atom, a C1-C3 alkyl group or others; R5 represents a group -OR42, a group (see formula II) or others.

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