Novel aminobenzamide derivative

Details Novel aminobenzamide derivative Novel aminobenzamide derivative

C - Chemistry, Metallurgy

07

D

C07D 277/46 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07D 277/56 (2006.01) C07D 401/12 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2488161

A compound represented by the formula (I): (I) [wherein R1 represents -S(O)p- A, -S-(O)q-B, or -O-D (wherein p and q each independently is 0 to 2; A represents optionally substituted linear C1-10 alkyl; B and D each independently represents an optionally substituted ring structure); R2 represents hydrogen, etc.; X1 and X2 each independently represents nitrogen or CH, provided that not both of X1 and X2 are nitrogen; and the structure has a nitrogen-containing, monocyclic or bicyclic heteroaryl group adjacent to the carbon atom bonded to the amide group] or a pharmaceutically acceptable salt of the compound. The compound has glucokinase activity and is useful for diabetes, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, diabetic arteriosclerosis, etc.

L'invention concerne un composé ou un sel pharmaceutiquement acceptable de formule (I), dans laquelle R¿1? est -S(O)¿p?-A, -S-(O)¿q?-B, ou -O-D (p et q valant indépendamment entre 0 et 2; A étant alkyle C¿1-10? linéaire éventuellement substitué; B et D étant chacun indépendamment c une structure cyclique substituée); R¿2? est hydrogène, etc.; X¿1? et X¿2? sont chacun indépendamment azote ou CH, à condition que les deux ne soient pas azote; et la structure présente un groupe hétéroayle monocyclique ou bicyclique contenant de l'azote, adjacent à l'atome de carbone lié au groupe amide. Le composé considéré à une activité glucokinase, et il est utile pour le traitement du diabète, de la néphropathie diabétique, de la rétinopathie diabétique, de la neuropathie diabétique, de l'artériosclérose diabétique, etc.

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