Novel aminocyclohexane derivatives

Details Novel aminocyclohexane derivatives Novel aminocyclohexane derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/20 (2006.01) A61K 31/135 (2006.01) C07C 233/23 (2006.01) C07C 233/74 (2006.01) C07C 235/54 (2006.01) C07C 235/84 (2006.01) C07C 255/57 (2006.01) C07C 271/24 (2006.01) C07C 271/52 (2006.01) C07C 271/56 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/34 (2006.01) C07C 275/38 (2006.01) C07C 275/40 (2006.01) C07C 291/04 (2006.01) C07C 307/08 (2006.01) C07C 307/10 (2006.01) C07C 311/07 (2006.01) C07C 311/13 (2006.01) C07C 335/14 (2006.01) C07C 335/16 (2006.01) C07C 3

Patent

CA 2418744

The present invention relates to compounds of formula (I) (see formula I) wherein U, V, W, A1, A2, A3, A4, A5, A6, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyper-proliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

L'invention concerne des composés de formule (I) dans laquelle U, V, W, A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, m et n sont tels que définis dans la description et les revendications et des sels pharmaceutiquement acceptables de ces derniers et/ou des esters pharmaceutiquement acceptables de ces derniers. Les composés sont utiles dans le traitement et/ou la prévention de maladies associées à 2,3-oxidosqualène-lanostérol cyclase, telles que l'hypercholestérolémie, l'hyperlipémie, l'artériosclérose, les maladies vasculaires, les mycoses, les calculs biliaires, les tumeurs et/ou les troubles hyperprolifératifs, ainsi que le traitement et/ou la prévention de l'intolérance au glucose et le diabète.

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