C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/234 (2006.01) A61K 31/7036 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2654561
Disclosed are: a novel aminoglycoside antibiotic which has an excellent anti-bacterial activity against an infection-inducing bacterium, particularly MRSA, and also has low renal toxicity; and a process for production of the antibiotic. More specifically, disclosed are: a compound represented by the formula (Ia) or a pharmacologically acceptable salt or solvate thereof, or a diastereomeric mixture of the compound, the salt or the solvate; an antibacterial agent comprising the compound, the salt, the solvate or the diastereomeric mixture; and a process for production of the compound. [Chemical formula 1] (Ia)
L'invention concerne un nouvel antibiotique de type aminoglycoside présentant une excellente activité antibactérienne contre une bactérie infectieuse, en particulier le staphylocoque doré résistant à la méticiline (MRSA), et présentant en outre une faible toxicité rénale. Cette invention se rapporte également à un procédé de production de cet antibiotique. La présente invention concerne de manière plus spécifique : un composé représenté par la formule (Ia), ou un sel ou un solvate pharmaceutiquement acceptable de ce composé; un agent antibactérien comportant ce composé, le sel, le solvate, ou un mélange diastéréoisomère; et un procédé de production dudit composé.
Abe Mitsuhiro
Akiyama Yoshihisa
Hiraiwa Yukiko
Hoshiko Shigeru
Ikeda Daishiro
Fetherstonhaugh & Co.
Meiji Seika Kaisha Ltd.
Microbial Chemistry Research Foundation
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