C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 5/06 (2006.01) A61K 31/7008 (2006.01)
Patent
CA 2646407
A new class of paromomycin-derived aminoglycosides (Formula I), which exhibit efficient stop-codon mutation suppression activity, low cytotoxicity and selectivity towards eukaryotic cells are provided. Also provided are processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
L'invention concerne un nouveau type d'aminoglycosides dérivés de la paromomycine présentant une activité efficace en termes de suppression de la mutation du codon stop, une faible cytotoxicité et une sélectivité pour les cellules eucaryotes. L'invention concerne également des procédés de préparation de ces aminoglycosides dérivés de la paromomycine et des produits intermédiaires correspondants, ainsi que des compositions pharmaceutiques les contenant et leurs utilisations dans le traitement de troubles génétiques.
Baasov Timor
Ben-Yosef Tamar
Hainrichson Mariana
Nudelman Igor
Rebibo-Sabbah Annie
Integral Ip
Technion Research & Development Foundation Ltd.
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