C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 3/00 (2006.01) A61P 9/12 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2497351
The invention concerns novel derivatives of general formula (I) and their pharmaceutically acceptable salts as kinase inhibitor and their use for preparing pharmaceutical compositions for preventing or treating diseases resulting from abnormal kinase activity such as, for example, those involved in neurodegenerative diseases, Alzheimer's disease, frontoparietal dementia, corticobasal degeneration, Pick's disease, cerebrovascular accidents, head and spine traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovary syndrome, syndrome X, immunodeficiency and cancer.
La présente invention concerne les nouveaux dérivés de formule générale (I) dans laquelle R3 est un radical (1-6C)alkyle, aryle, aryle(1-6C)alkyle, hétéroaryle, hétéroaryle(1-6C)alkyle, aryle ou hétéroaryle fusionné ô un cycloalkyle (1-10C), hétérocycle, hétérocycloalkyle, cycloalkyle, adamantyle, polycycloalkyles, alkényle, alkynyle, CONR1R2, COOR1, SO2R1, C=;NH)R1, C=;NH)NR1; R5, R6 sont indépendamment l'un de l'autre choisis parmi les radicaux suivant halogène, CN, NO2, NH2, OH, COOH, C(O)OR8, -O-C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, -O-SO2R8, -SO2-O-R8, trifluorométhyle, trifluorométhoxy, (1- 6C)alkyle, (1-6C)alcoxy, aryle, aryle(1-6C)alkyle, hétéroaryle, hétéroaryle(1- 6C)alkyle, hétérocycle, cycloalkyle, alkényle, alkynyle , adamantyle, polycycloalkyles.
Babin Didier
Dutruc-Rosset Gilles
Halley Franck
Lesuisse Dominique
Rooney Thomas
Aventis Pharma S.a.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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