Novel aminophenyl piperazine or aminophenyl piperidine...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 409/12 (2006.01) A61K 31/395 (2006.01) A61P 43/00 (2006.01) C07D 233/54 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2425416

The invention concerns compounds corresponding to general formula (I), wherein, in particular: W represents hydrogen, COR¿6?, CSR¿6?, SO¿2?R¿6?, CO(CH¿2?)¿n?R¿6?, (CH¿2?)¿n?R¿7?; X represents CH or N; Y represents (CH¿2?)¿n?, CO, CH¿2?CO, CH=CHCO, CH¿2?CH¿2?CO; Z represents a heterocycle. When Z = pyridine, then Y is other than CO. R¿1? represents hydrogen, C¿1?-C¿6? alkyl, halogen, OCH¿3?, CF¿3?; R¿2? and R¿3?, identical or different, represent hydrogen, C¿1?-C¿6? alkyl; R¿4? represents a) hydrogen, b) C¿1?-C¿6? alkyl, c) an aryl, d) a heterocycle; R¿5? represents hydrogen, COR¿7?R¿8?, SO¿2?R¿7?, CO(CH¿2?)¿n?SR¿7?, CO(CH¿2?)¿n?OR¿7?, CONR¿7?R¿8?, CO(CH¿2?)¿m?COR¿7?; R¿6? represents a) a phenyl or a naphthyl, b) a C¿1?-C¿6? alkyl, a cycloalkyl, c) a heterocycle, d) NR¿7?R¿8?; R¿7? and R¿8?, identical or different, represent a) hydrogen, C¿1?-C¿15? alkyl, b) a heterocycle, c) an aryl; n represents 0 to 10; m represents 2 to 10; provided that when Z represents a quinozaline or benzimidazole group, then R¿5? is other than CH¿2?Ph or methyl and n is other than zero.

L'invention concerne des composés répondant à la formule générale (I), dans laquelle notamment : W représente : hydrogène, COR6, CSR6, SO2R6, CO(CH2)nR6, (CH2)nR7 ; X représente : CH ou N ; Y représente : (CH2)n, CO, CH2CO, CH=CHCO, CH2CH2CO ; Z représente un hétérocycle. Quand Z = pyridine alors Y est différent de CO. R1 représente : Hydrogène, C1-C6 alkyle, halogène, OCH3, CF3. R2 et R3, identiques ou différents représentent : Hydrogène, C1-C6 alkyle. R4 représente : a) Hydrogène ; b) C1-C6 alkyle ; c) un aryle ; d) un hétérocycle. R5 représente : Hydrogène, COR7, SO2R7, CO(CH2)nSR7, CO(CH2)nOR7, CONR7R8, CSNR7R8, CO(CH2)mCOR7. R6 représente : a) un phényle ou un naphtyle ; b) un C1- C6 alkyle, un cycloalkyle ; c) un hétérocycle ; d) NR7R8. R7 et R8, identiques ou différents, représentent : a) Hydrogène ; C1-C15 alkyle ; b) un hétérocycle ; c) un aryle. n représente : 0 à 10. m représente : 2 à 10 ; à la condition toutefois que, lorsque Z représente un groupement quinazoline ou benzimidazole, alors R5 est différent de CH2Ph ou Méthyl et n est différent de zéro.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Novel aminophenyl piperazine or aminophenyl piperidine... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel aminophenyl piperazine or aminophenyl piperidine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel aminophenyl piperazine or aminophenyl piperidine... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-2091353

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.