Novel aminopyridine derivatives as mglur5 antagonists

Details Novel aminopyridine derivatives as mglur5 antagonists Novel aminopyridine derivatives as mglur5 antagonists

C - Chemistry, Metallurgy

07

D

C07D 213/73 (2006.01) A61K 31/44 (2006.01) A61K 31/444 (2006.01) A61P 25/00 (2006.01) C07D 213/74 (2006.01)

Patent

CA 2517083

The invention relates to novel aminopyridine derivatives of formula (I) wherein R1 is methyl an R4 and amino group NR6R7 and R5 forms an arylalkynyl- or heteroarylalkynyl-group. The compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGIuR5 receptors.

L'invention concerne de nouveaux dérivés d'aminopyridine de formule (I), dans laquelle R1 représente méthyle et R4 un groupe amine, NR¿6?R¿7? et R¿5? formant un groupement arylalkynyle ou hétéroarylalkynyle. Ces composés sont utiles pour prévenir ou traiter des troubles du système nerveux central et d'autres troubles modulés par des récepteurs de mGluR5.

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