Novel aminotriazolone compounds, method for preparing same...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/12 (2006.01) A61K 31/4196 (2006.01) A61P 9/12 (2006.01) C07D 249/14 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2424802

The invention concerns a compound of formula (I), wherein: R¿3? represents a hydrogen atom or an alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl group; R¿4? represents a group of formula (II), wherein B represents a monocyclic or polycyclic group, aromatic or not, containing 3 to 10 vertices, capable of containing 1 to 3 heteroatoms; R¿5 ?represents a hydrogen atom or an alkyl group; A represents a group selected among -A¿2?-, -A¿1?-A¿2?-, -A¿2?-A¿1?-, or -A¿1?-A¿2?-A¿1?-; V represents a bond or a -CH¿2?, -CO-, -CS-, -CH¿2?-NH- or CH=N- group, or V and R¿3? together form with the groups -A- and -N-R¿4? which bears them a -A-CH=NR¿4? group; and their use for treating neuropeptide Y-related (NPY) pathologies.

Composé de formule (I), dans laquelle: R3 représente un atome d'hydrogène ou un groupement alkyle, alkényle, alkynyle, aryle, hétéroaryle, cycloalkyle ou hétérocycloalkyle; R4 représente un groupement de formule (II), dans laquelle B représente un groupement mono ou polycyclique, aromatique ou non, contenant 3 à 10 sommets, pouvant contenir de 1 à 3 hétéroatomes, R5 représente un atome d'hydrogène ou un groupement alkyle, A représente un groupement choisi parmi - A2-, -A1-A2, -A2-A1- ou -A1-A2-A1-; V représente une liaison ou un groupement - CH2-, -CO-, -CS-, -CH2-NH- ou -CH=N-, ou V et R3 forment ensemble avec les groupements -A- et -N-R4 qui les portent un groupement -A-CH=N-R4, et leur utilisation dans le traitement des pathologies liées au neuropeptide Y (NPY).

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