C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2339948
This invention pertains to the field of cancer genetics and cytogenetics. In particular, this invention pertains to the identification of a novel amplicon on human chromosome 20 which is associated with cancer. More particularly this invention pertains to the identification of a novel "amplicon" or genomic nucleic acid in a region of amplification at about 20q13.2 which has been associated with a variety of cancers, particularly breast cancer. The novel amplicon of the invention can be used as a probe specific for this region of 20q13.2 as well as for the diagnosis and prognosis of various cancers. Also provided are kits for screening for the presence and copy number of the novel amplicon of the invention in a sample containing human nucleic acid.
L'invention concerne le domaine de la génétique et de la cytogénétique du cancer. L'invention a notamment trait à l'identification d'un nouvel amplicon du chromosome humain 20 qui est associé au cancer. Plus particulièrement, l'invention a trait à l'identification d'un nouvel amplicon ou acide nucléique génomique d'une région d'amplification se situant à environ 20q13,2, qui a été associée à divers cancers, notamment au cancer du sein. Le nouvel amplicon de l'invention peut être utilisé comme sonde spécifique de cette région de 20q13,2 ainsi que pour le diagnostic et le pronostic de divers cancers. L'invention concerne également des trousses permettant de détecter la présence et le nombre de copies du nouvel amplicon dans un échantillon contenant de l'acide nucléique humain.
Albertson Donna
Collins Colin
Gray Joe
Pinkel Daniel
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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