Novel analgesic and immunomodulatory cannabinoids

Details Novel analgesic and immunomodulatory cannabinoids Novel analgesic and immunomodulatory cannabinoids

C - Chemistry, Metallurgy

07

D

C07D 311/80 (2006.01) A61K 31/35 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2340445

Disclosed are novel compounds represented by the following structural formula: R-X-Y; and physiologically acceptable salts thereof. R is a tricyclic core of a cannabinoid or substituted cannabinoid. X is a covalent bond, -CH2- or -CHR1-, wherein R1 is a C1 to C3 substituted or unsubstituted alkyl group. Y is a heterocyclic ring, a substituted heterocyclic ring, a carbocyclic ring, a substituted carbocyclic ring, a fused bicyclic ring system, a substituted fused bicyclic ring system, a bridged bicyclic ring system, a substituted bridged bicyclic ring system, a bridged tricyclic ring system or a substituted bridged tricyclic ring system. Also disclosed is a method of stimulating a CB1 and/or CB2 receptor in a subject. The method comprises administering to the subject a therapeutically effective amount of R-X-Y.

L'invention concerne de nouveaux composés, représentés par la formule structurelle R-X-Y, et leurs sels pharmaceutiquement acceptables. R est un coeur tricyclique d'un cannabinoïde ou d'un cannabinoïde substitué ; X est une liaison covalente, -CH2 ou -CHR1, où R1 est un groupe alkyle C1-C3 substitué ou non substitué ; Y est un noyau hétérocyclique, un noyau hétérocyclique substitué, un noyau carbocyclique, un noyau carbocyclique substitué, un système de noyau bicyclique condensé, un système de noyau bicyclique condensé substitué, un système de noyau bicyclique ponté, un système de noyau bicyclique ponté substitué, un système de noyau tricyclique ponté ou un système de noyau tricyclique ponté substitué. L'invention concerne également une technique qui permet de stimuler un récepteur CB1 et/ou CB2 chez un sujet et qui consiste à administrer audit sujet une quantité thérapeutiquement efficace de R-X-Y.

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