C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/53 (2006.01) A61K 31/18 (2006.01) A61K 31/202 (2006.01) A61K 38/49 (2006.01) C07C 311/51 (2006.01)
Patent
CA 2332272
The present invention includes 16-HETE analogs of formula (I), wherein R, R2 and R3 have the meanings given in the description, which are agonists and antagoninists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke.
La présente invention concerne des analogues de 16-HETE représentés par la formule (I) dans laquelle R, R¿2? et R¿3? ont les notations données dans la description, qui constituent des agonistes et des antagonistes de 16-HETE. Les compositions peuvent être formulées de façon à constituer des formulations pharmaceutiquement acceptables. L'invention concerne également des procédés et des produits servant à inhiber l'adhérence de neutrophiles et l'agrégation de neutrophiles au moyen des agonistes de 16-HETE. Un procédé de l'invention comporte l'administration d'un agoniste de 16-HETE en combinaison avec un agent thrombolytique à un patient atteint d'une attaque d'apoplexie thrombo-embolique.
Balazy Michael
Bednar Martin M.
Falck John R.
Gross Cordell E.
Board Of Regents The University Of Texas System
New York Medical College
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Of Vermont And State Agricultural College
University Of Vermont
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