A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/12 (2006.01) A61K 9/00 (2006.01) A61K 9/72 (2006.01) A61K 31/702 (2006.01) A61K 31/7036 (2006.01) A61K 31/715 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2179305
An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100 % of susceptible bacteria. Aminoglycoside is formulated in 5 ml solution of a quater normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 µ, produced by a jet or ultrasonic nebulizer.
L'invention concerne une formulation d'aminoglucoside destinée à être administrée sous forme d'aérosol. La formulation d'aminoglucoside concentré contient une dose efficace d'aminoglucoside pouvant inhiber 95 à 100 % des bactéries qui lui sont sensibles. L'aminoglucoside est contenu dans une solution saline au quart de 5 ml présentant un pH compris entre 5,5 et 6,5. L'invention concerne également un procédé de traitement d'infections endobronchiques au moyen d'une composition administrée sous la forme d'un aérosol, présentant un diamètre moyen des particules de substance à administrer compris principalement entre 1 et 5 µ, lesdites particules étant produites au moyen d'un nébuliseur à pression ou ultrasonique.
Montgomery Alan B.
Ramsey Bonnie W.
Smith Arnold L.
Children's Hospital & Medical Center
Gowling Lafleur Henderson Llp
Novartis Ag
Pathogenesis Corporation
Seattle Children's Hospital
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