C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 309/15 (2006.01) A61K 31/166 (2006.01) A61K 31/343 (2006.01) A61K 31/42 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 261/08 (2006.01) C07D 307/81 (2006.01)
Patent
CA 2678265
The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistence and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
La présente invention propose de nouveaux composés de formule (I) et les sels et co-cristaux pharmaceutiquement acceptables de ceux-ci qui ont une activité antagoniste ou agoniste inverse du récepteur au glucagon. La présente invention propose en outre des compositions pharmaceutiques les comprenant ainsi que des procédés de traitement, de prévention, de retardement de la durée avant la déclaration ou de réduction du risque de développement ou de progression d'une maladie ou d'une condition pour laquelle un ou plusieurs antagonistes du récepteur au glucagon est indiqué, y compris le diabète de type I et II, l'insulinorésistance et l'hyperglycémie. La présente invention propose également des procédés de préparation des composés de formule I, y compris les sels et co-cristaux de ceux-ci, et des compositions pharmaceutiques les comprenant.
Boyer Serge Henri
Chen Mingwei
Craigo William
Dang Qun
Gomez-Galeno Jorge E.
Mcfadden Fincham
Metabasis Therapeutics Inc.
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