Novel anthracycline derivatives having...

Details Novel anthracycline derivatives having... Novel anthracycline derivatives having...

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01) A61K 31/70 (2006.01) C07H 13/02 (2006.01) C07H 15/244 (2006.01)

Patent

CA 2225336

7-O-(4-Amino-2,4,6-trideoxy-2-fluoro-.alpha.-L-mannopyranosyl)-daunomycin or - adriamycin represented by general formula (I), wherein R represents hydrogen or hydroxy. These novel compounds are excellent in antitumor activity and highly soluble in water, which makes them useful as an antitumor agent.

L'invention concerne la 7-O-(4-amino-2,4,6-tridésoxy-2-fluoro-.alpha.-L-mannopyranosyl)-daunomycine ou -adriamycine, représentée par la formule générale (I). Dans cette formule, R représente un hydrogène ou hydroxy. Ces nouveaux composés ont une très bonne activité contre les tumeurs et ils sont très solubles dans l'eau, ce qui les rend utiles pour le traitement des tumeurs

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