C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01)
Patent
CA 2738782
The present invention relates to a novel isolated antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the CXCR4 homodimers and/or heterodimers. More particularly, the present invention relates to the 414H5 and 515H7 antibodies, specific to the CXCR4 protein, as well as their use for the treatment of cancer. Pharmaceutical compositions composed of such antibodies and a process for the selection of such antibodies are also covered.
La présente invention concerne un nouvel anticorps isolé, ou les composés dérivés ou des fragments fonctionnels de celui-ci, capables de se lier à CXCR4 mais également dinduire des changements de conformation des homodimères et/ou hétérodimères de CXCR4. Plus particulièrement, la présente invention concerne les anticorps 414H5 et 515H7, spécifiques de la protéine CXCR4, ainsi que leur utilisation pour le traitement du cancer. La présente invention concerne en outre des compositions pharmaceutiques contenant de tels anticorps et un procédé pour la sélection de tels anticorps.
Grenier-Caussanel Veronique
Klinguer-Hamour Christine
Goudreau Gage Dubuc
Pierre Fabre Medicament
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