Novel anti-estrogenic steroids, and associated...

Details Novel anti-estrogenic steroids, and associated... Novel anti-estrogenic steroids, and associated...

C - Chemistry, Metallurgy

07

J

C07J 43/00 (2006.01) C07J 41/00 (2006.01) A61K 9/02 (2006.01)

Patent

CA 2281844

Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependant disorders. Preferred compounds have 1,3,5-estratiene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5-estratienes. Therapeutic methods and pharmaceutical compositions are provided as well.

L'invention concerne de nouveaux composés anti-oestrogènes utiles pour traiter divers troubles, notamment les troubles dépendants des oestrogènes. Les composés préférés ont un noyau 1,3,5-estratriène et sont substitués en C17 ou C11 par un groupe moléculaire qui les rend capables de bloquer par compétition la fixation de l'oestrogène sur son récepteur. Les composés particulièrement préférés sont les 17-désoxy-1,3,5-estratriènes. L'invention concerne également des méthodes thérapeutiques et des compositions pharmaceutiques.

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