Novel anti-igf-ir antibodies and uses thereof

Details Novel anti-igf-ir antibodies and uses thereof Novel anti-igf-ir antibodies and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C07K 16/46 (2006.01) C12N 5/18 (2006.01) C12N 5/20 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2616099

The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR). The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF- IR, stimulated either by IGF1 and/or IGF2, or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR and/or the IGF-I / Insulin hybrid receptor.

L'invention porte sur de nouveaux anticorps anti IGF-IR (récepteur du facteur de croissance insulinomimétique de type I) se fixant spécifiquement à l'IGF-IR. L'invention porte également sur l'utilisation de ces anticorps comme médicament de traitement prophylactique et/ou thérapeutique de cancers surexprimant l'IGF-IR, stimulés soit par l'IGF1 et/ou l'IGF2, et de toute pathologie liée à la surexpression dudit récepteur. L'invention porte en outre sur des processus et des trousses de diagnostic de maladies liées à la surexpression de l'IGF-IR et/ou du récepteur hybride de l'IGF-I et de l'insuline.

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