Novel anti-il 13 antibodies and uses thereof

Details Novel anti-il 13 antibodies and uses thereof Novel anti-il 13 antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01) A61M 15/00 (2006.01)

Patent

CA 2550651

The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

La présente invention concerne des anticorps anti-IL13 se fixant de manière spécifique et avec une affinité élevée à L'IL13 humaine glycosylée et non glycosylée, ne se fixant pas à l'IL13 de souris et neutralisant l'activité de l'IL13 humaine à un rapport molaire approximatif de 1:2 (MAb:IL13). L'invention concerne également l'utilisation desdits anticorps dans le traitement de maladies induites par l'IL13, tel que les maladies allergiques, notamment l'asthme, l'asthme allergique, l'asthme mon allergique (intrinsèque), la rhinite allergique, la dermatite atopique, la conjonctivite allergique, l'eczéma, l'urticaire, les allergies alimentaires, la maladie pulmonaire obstructive chronique, la rectocolite hémorragique, l'infection à RSV, l'uvéite, la sclérodermie et l'ostéoporose.

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