C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 38/12 (2006.01) A61P 31/04 (2006.01) C12P 17/16 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2649480
This invention relates to a novel purified compound PM181104, of formula (I) of molecular weight 1514 and molecular formula C69H66N18O13S5; which is obtained by fermentation of the microorganism belonging to Kocuria species (ZMA B-1 / MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging to Kocuria species (ZMA B-1 / MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.
L'invention concerne un nouveau composé PM181104 purifié, de formule (I) à poids moléculaire 1514 et formule moléculaire C69H66N18O13S5. Ce composé peut être obtenu par fermentation de microorganismes appartenant à l'espèce Kocuria (ZMA B-1/MTCC 5269). L'invention concerne également toutes les formes stéréoisomères et toutes les formes tautomères du composé PM181104 ainsi que des sels et des dérivés pharmaceutiquement acceptables de ceux-ci, notamment des esters et des éthers. Elle concerne, en outre, des procédés de production de ce/ces nouveau(x) composé(s) antibactérien(s), de microorganismes appartenant à l'espèce Kocuria (ZMA B-1/MTCC 5269), et de compositions pharmaceutiques contenant ce/ces nouveau(x) composé(s) en tant que principe actif et son/leur utilisation dans des médicaments destinés au traitement et à la prévention de maladies entraînées par des infections bactériennes.
D'souza Lisette
David George Saji
Devi Prabha
Eruch Patel Zarine
Eyyammadichiyil Sreekumar Sankaranarayanan
Council Of Scientific And Industrial Research
Piramal Life Sciences Limited
Riches Mckenzie & Herbert Llp
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