Novel antibacterial compounds

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 19/067 (2006.01) A61K 31/7072 (2006.01) A61P 31/04 (2006.01) C07H 19/06 (2006.01) C12P 17/16 (2006.01) C12P 19/38 (2006.01)

Patent

CA 2337225

The present invention relates to ester. ether and N-alkylcarbamoyl derivatives of compound (Ia) and pharmaceutically acceptable salts thereof. These compounds exhibit excellent antibacterial activity and are useful for the treatment or prevention of bacterial infections. Image (wherein R1 is a hydrogen atom or a methvl group; R1a is a hydrogen atom, a protecting group for a hydroxy group, or a methvl group; R3 is a hydrogen atom or a protecting group for a hydroxv group; R4 a is a hydrogen atom, a hydroxv group or a protected hydroxy group; R5 is a hydrogen atom or a protecting group for a hydroxy group; and X is a methylene group or a sulfur atom).

L'invention concerne des esters, des éthers et des carbamoyl N-alkylates pharmaceutiquement acceptables dérivés des composés représentés par la formule générale (Ia), ainsi que des sels pharmaceutiquement acceptables de ces composés, lesquels composés présentent une excellente activité antibactérienne et sont utiles dans le traitement et la prévention des maladies infectieuses. Dans la formule (Ia), R<1> représente hydrogène ou méthyle; R<2>a représente hydrogène, un groupe de protection hydroxyle ou un méthyle; R<3> représente hydrogène ou un groupe de protection hydroxyle; R<4>a représente hydrogène ou un hydroxyle éventuellement protégé; R<5> représente hydrogène ou un groupe de protection hydroxyle; et X représente un méthylène ou un soufre.

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