C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/205 (2006.01) C07K 14/195 (2006.01)
Patent
CA 2711462
The present invention relates to a new antibiotic peptide and a usage thereof, which are derived from ribosomal protein Ll, RPL1 of Helicobacter pylori. Specifically, the antibiotic peptide comprising the amino acid sequence of SEQ. ID. NO:1 derived from ribosomal protein Ll, RPL1 of Helicobacter pylori is substituted with a Phenylalanine, which is situated at the fist and the eighth position from the antibiotic peptide, or in addition an Asparagine, which is situated at the thirteenth position of the antibiotic peptide, is substituted with lysine, wherein the produced peptides have maintained more decreased cytotoxicity when comparing to the existing antibiotic peptides and can be used as a safe antibiotics by showing more antibacterial activity.
La présente invention concerne de nouveaux peptides antibiotiques et leur utilisation. Lesdits peptides sont issus de la protéine ribosomale L1, RPL1 d'Helicobacter pylori. Plus particulièrement, le peptide antibiotique comportant la séquence des acides aminés de SEQ. ID. NO:1, issu de la protéine ribosomale L1, RPLl d'Helicobacter pylori est substitué par une phénylalanine, qui est située à la première et à la huitième position du peptide antibiotique, ou bien, en plus, une asparagine, qui est située à la treizième position du peptide antibiotique, est substituée par la lysine, les peptides obtenus ayant maintenu une cytotoxicité davantage réduite par comparaison avec les peptides antibiotiques existants et peuvent être utilisés comme antibiotiques sans danger tout en présentant une plus grande activité antibactérienne.
Hahm Kyung-Soo
Lee Jong-Kook
Park Seong-Cheol
Park Yoonkyung
Industry-Academic Cooperation Foundation Chosun University
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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