Novel antibody molecules and nucleic acids binding to fungal...

Details Novel antibody molecules and nucleic acids binding to fungal... Novel antibody molecules and nucleic acids binding to fungal...

C - Chemistry, Metallurgy

07

K

C07K 16/14 (2006.01) A61K 35/00 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) C07K 16/18 (2006.01) C12N 15/10 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2685136

An scFv peptide comprising a VH domain and a VL domain linked by an amino acid spacer is disclosed. The VH domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 64. The VL domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 66. The scFv peptide also comprises the substitution or deletion of an amino acid in the VH domain at the position corresponding to C28.

L'invention porte sur un peptide scFv comprenant un domaine VH et un domaine VL liés par un espaceur d'acide aminé. Le domaine VH comprend une séquence présentant au moins 80 % d'identité avec la séquence SEQ ID No 64. Le domaine VL comprend une séquence présentant au moins 80 % d'identité avec la séquence SEQ ID No 66. Le peptide scFv comprend également la substitution ou la délation d'un acide aminé du domaine VH à la position correspondant à C28.

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