C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/745 (2006.01) A61K 35/16 (2006.01) A61K 38/36 (2006.01) A61K 39/395 (2006.01) C07K 16/36 (2006.01) C12Q 1/56 (2006.01) C12Q 1/68 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2154080
A novel blood anticoagulant activity named APC-cofactor 2 activity that is the second cofactor activity to activated Protein C (= APC) is described. The cofactor activity is likely to be associated with Factor V because it behaves as a protein that can be enriched from plasma with methods that are similar to such methods for Factor V. On SDS-PAGE the enriched fraction gives rise to three molecular bands at 175-250 kd and 100-180 kd and 330 kd, respectively. Different aspects are described, such as preparations enriched or deficient in the cofactor activity; antibody preparations specific for the Factor V sites associated with APC-cofactor 2 activity; diagnostic and therapeutic uses in connecton with the treatment of disorders related to deficiencies in APC-cofactor 2 activity, Protein C and/or Protein S as well as different uses of preparations enriched in APC-cofactor 2 activity (normal Factor V), Protein C/APC and/or Protein S. APC-cofactor 2 activity may also be used therapeutically in connection with other diseases in which administration of the cofactor is beneficial to the patient.
Dahlback Bjorn
Gowling Lafleur Henderson Llp
T.a.c. Thrombosis And Coagulation Ab
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