C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2264258
A peptide comprising at least the following amino acid sequence: Lys Xa1 Phe Lys Arg Ile Val Xa2 Arg Ile Xaa Xa2 Phe Leu Arg Xa2 Leu Val (SEQ ID NO: 1) wherein, Xa1 represents a hydrophobic amino acid residue, each of Xa2 independently represents a hydrophilic amino acid residue, and Xaa represents an arbitrary amino acid residue; an antimicrobial agent, a medicine including a bacterial infection-treating agent and an endotoxin shock suppressant which each comprise the peptide as an active ingredient; and an endotoxin-removing agent comprising the peptide immobilized to an insoluble carrier.
L'invention porte sur un peptide contenant au moins la séquence d'acides aminés suivante : Lys Xa1 Phe Lys Arg Ile Val Xa2 Arg Ile Xaa Xa2 Phe Leu Arg Xa2 Leu Val (SEQ ID Nº: 1) dans laquelle Xa1 représente un acide aminé hydrophobe, chacun des Xa2 représente de façon distincte un acide aminé hydrophile et Xaa représente un acide aminé arbitraire; un agent antimicrobien, un médicament comprenant un agent traitant les infections bactériennes et un agent inhibant le choc endotoxique qui contiennent chacun le peptide comme ingrédient actif; et un agent éliminant les endotoxines comprenant le peptide immobilisé sur un transporteur insoluble.
Seikagaku Corporation
Smart & Biggar
LandOfFree
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