Novel antimicrobial peptides from bovine neutrophils

Details Novel antimicrobial peptides from bovine neutrophils Novel antimicrobial peptides from bovine neutrophils

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/117 (2006.01) C07K 7/06 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2155739

The present invention provides a new family of cysteine-rich antimicrobial peptides isolated from bovine neutrophils herein named beta defensins. Thirteen structurally homologous peptides were purified to homogeneity from a granule-rich cytoplasmic fraction of purified blood neutrophils. These antimicrobial compounds are useful in human and veterinary medicine, and as agents in agricultural, food science, and industrial applications.

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