Novel antimicrobial peptides with heparin binding activity

Details Novel antimicrobial peptides with heparin binding activity Novel antimicrobial peptides with heparin binding activity

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61P 31/00 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2523998

The invention relates to an antimicrobial peptide with heparin binding activity, being derived from endogenous mammalian proteins being substantially free from antimicrobial activity selected from the group consisting of laminin isoforms, complement factor C3, histidin rich glycoprotein and kininogen and having from 10 to 36 amino acid residues, wherein the antimicrobial peptide consists of at least four amino acid residues selected from the group consisting of K, R and H. The invention also relates to pharmaceutical compositions comprising said antimicrobial peptide and use of the antimicrobial peptide and/or antimicrobial/pharmaceutical composition.

L'invention concerne un peptide antimicrobien présentant une activité de liaison à l'héparine, ce peptide étant dérivé de protéines de mammifères endogènes sensiblement dépourvues d'activité antimicrobienne choisies dans le groupe constitué par des isoformes de laminine, un facteur de complément C3, une glycoprotéine riche en histidine et un kininogène, et renfermant entre 10 et 36 résidus d'acides aminés. Ledit peptide antimicrobien comprend au moins quatre résidus d'acides aminés choisis dans le groupe constitué par K, R et H. L'invention concerne également des compositions pharmaceutiques contenant ce peptide antimicrobien ainsi que l'utilisation du peptide antimicrobien et/ou de la composition antimicrobienne/pharmaceutique.

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