C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2743971
The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.
L'invention concerne de nouveaux composés phényloxazolidinone de formule (I), leurs analogues pharmaceutiquement acceptables, formes tautomères, stéréo-isomères, polymorphes, promédicaments, métabolites, sels ou solvants. Cette invention concerne également les procédés de synthèse desdits nouveaux composés de formule (I) ou de leurs analogues pharmaceutiquement acceptables, formes tautomères, stéréo-isomères, polymorphes, promédicaments, métabolites, sels ou solvants. L'invention se rapporte en outre à des compositions pharmaceutiques comprenant les nouveaux composés de formule (I), et des procédés d'utilisation correspondants. Les composés selon l'invention peuvent être utilisés en tant qu'agents antimicrobiens agissant efficacement contre plusieurs agents pathogènes aérobie et/ou anaérobie à gram positif et/ou à gram négatif tels que les espèces polypharmacorésistantes de Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, les organismes à l'épreuve des acides tels que Mycobacterium tuberculosis, ainsi que les espèces de Staphylococcus et d'Enterococcus résistantes au linézolide.
Das Jagattaran
Jain Rajesh
Kanwar Sandeep
Magadi Sitaram Kumar
Sharma Sudhir Kumar
Panacea Biotec Ltd.
Sim & Mcburney
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