A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/407 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2212237
Compounds, isolated from the bacteria Xenorhabdus bovienii, having the formula (see fig. I) Or (see fig. II) wherein n=0,1, or 2;R1 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, or heterocyclyl group; R2 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or group acyl,; R3 = hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclyl group or the salts thereof have antineoplastic activity. The invention provides pharmaceutical compositions containing the compounds and the methods for employing them as medicaments, particularly in the treatment of human and animal cancers.
Composés isolés provenant de la bactérie Xenorhabdus bovienii, de formule (voir fig. I) ou (voir fig. II), où : n = 0, 1, ou 2; R1 est un hydrogène, un groupe cycloalkyle, aryle, aralkyle, hétérocyclyle ou alkyle avec ou sans substitution; R2 est un hydrogène ou un groupe cycloalkyle, aryle, aralkyle, hétérocyclyle, acyle ou alkyle avec ou sans substitution; R3 est un hydrogène, un groupe alkyle, cycloalkyle, aralkyle, aryle ou hétérocyclyle; ou encore leurs sels; tous ces composés possèdent des propriétés anticancéreuses. L'invention porte sur des compositions pharmaceutiques contenant ces composés et sur des méthodes qui les utilisent, particulièrement pour le traitement des cancers aussi bien chez l'homme que chez l'animal.
Chen Genhui
Li Jianxiong
Webster John M.
Blake Cassels & Graydon Llp
Chen Genhui
Li Jianxiong
Webster John M.
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