C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/12 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2670039
The present invention relates to novel isolated antibodies, or the derived compounds or functional fragments of same, capable of inhibiting the proliferation of tumor cells in vitro and/or in vivo, said antibodies having been obtained by functional screening. More particularly, the present invention relates to the 6F4 antibody, specific to the JAM-A protein, as well as its use for the treatment of cancer. Pharmaceutical compositions composed of such antibodies are also covered.
La présente invention porte sur de nouveaux anticorps isolés ou sur les composés ou fragments fonctionnels dérivés de ceux-ci qui peuvent inhiber la prolifération de cellules tumorales in vitro et/ou in vivo, lesdits anticorps ayant été obtenus par criblage fonctionnel. Plus particulièrement, la présente invention porte sur l'anticorps 6F4 spécifique de la protéine JAM-A ainsi que sur son utilisation pour le traitement du cancer. Des compositions pharmaceutiques composées de tels anticorps sont également couvertes.
Bes Cedric
Corvaia Nathalie
Goetsch Liliane
Haeuw Jean-Francois
Goudreau Gage Dubuc
Pierre Fabre Medicament
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