C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/32 (2006.01) A61K 38/16 (2006.01) C07K 14/325 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2234794
The present invention provides an isolated and purified protein derived from Bacillus thuringiensis subspecies thuringiensis, having a molecular weight of approximately 20 kDa of SDS-PAGE, said protein having the partial amino acid sequence shown in SEQ ID No. 1, and wherein said protein displays cytotoxic effects against tumor cells. Also provided is a method of treating a neoplastic cell comprising administering a therapeutically effective dose of the composition of the present invention to said cell.
La présente invention concerne une protéine isolée et purifiée dérivée de Bacillus thuringiensis sous-espèce thuringiensis, présentant un poids moléculaire d'environ 20 kDa de SDS-PAGE, ladite protéine possédant la séquence aminoacide partielle figurant dans l'identification de séquence numéro 1, et présentant des effets cytotoxiques contre les cellules tumorales. Est également décrit un procédé pour traiter une cellule néoplasique, consistant à administrer à cette dernière une dose thérapeutiquement efficace de la composition décrite.
Aggarwal Bharat B.
Padilla Cristina Rodriguez
Borden Ladner Gervais Llp
Research Development Foundation
Universidad Autonoma de Nuevo Leon
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