Novel antisense inhibition of rad51

A - Human Necessities – 61 – K

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A61K 31/7088 (2006.01) A61K 31/40 (2006.01) A61K 31/4184 (2006.01) A61K 31/7084 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2362109

Provided herein are methods for inhibiting cell proliferation in an individual comprising administering to the individual a composition comprising a Rad51 inhibitor. Also provided herein is a method for inhibiting the growth of a cell comprising administering to said cell a composition comprising a Rad51 inhibitor. Such methods can further include the step of providing radiation or DNA damaging agents after administration of said Rad51 inhibitor. Also described herein are methods which are performed in vivo and/or on cancerous cells.

La présente invention concerne des techniques permettant d'inhiber la prolifération des cellules chez un individu. Cette technique consiste à administrer à cet individu une composition contenant un inhibiteur de Rad51. Cette invention concerne aussi une technique permettant d'inhiber la croissance d'une cellule, qui consiste à administrer dans ladite cellule une composition contenant un inhibiteur de Rad51. Ces techniques peuvent aussi comprendre une radiothérapie ou l'apport d'agents s'attaquant à l'ADN après l'administration de l'inhibiteur de Rad51. L'invention concerne enfin des techniques réalisées in vivo et/ou sur des cellules cancéreuses.

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