Novel antitumor and antileukemia substances, preparation...

Details Novel antitumor and antileukemia substances, preparation... Novel antitumor and antileukemia substances, preparation...

C - Chemistry, Metallurgy

07

C

C07C 49/753 (2006.01) A61K 31/085 (2006.01) A61K 31/12 (2006.01) C07C 43/23 (2006.01) C07C 45/78 (2006.01)

Patent

CA 2192711

A 3-(3-hydroxy-4-methoxy-benzyl)-7-methylene-1-vinyl-2,3,3a,4,7,7a-hexa-hydro- indene-4-one of formula (I), and a 3-(3-hydroxy-4-methoxy-benzyl)-4-hydroxy-7- methyl-1-vinyl-indane of formula (II), stereoisomeric forms thereof, a method for obtaining same from the plant Ottelia alismoides, and pharmaceutical compositions containing said substances, are disclosed. The novel substances of formula (I) or (II) have remarkable antitumor and antileukemia properties.

La 3-(3-hydroxy-4-méthoxy-benzyl)-7-méthylène-1-vinyl-2, 3, 3a, 4, 7, 7a-hexahydro-indène-4-one de formule (I), et le 3-(3-hydroxy-4-méthoxy-benzyl)-4-hydroxy-7-méthyl-1-vinyl-indane de formule (II), leurs formes stéréoisomères, un procédé d'obtention à partir de la plante Ottelia alismoïdes et les compositions pharmaceutiques qui les contiennent. Les nouvelles substances de formule (I) ou (II) présentent des propriétés antitumorales et antileucémiques remarquables.

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