A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/49 (2006.01) A61K 31/20 (2006.01) A61K 31/202 (2006.01) A61K 31/23 (2006.01) A61K 31/35 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/525 (2006.01) A61K 31/60 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2256578
The present invention provides methods and products for inhibiting neutrophil adhesion and neutrophil aggregation. The invention includes a method for treating a subject to inhibit neutrophil adhesion and neutrophil aggregation by administering 16-hydroxyeicosatetraenoic acid (16-HETE) to the subject. 16- HETE is an arachidonic acid metabolite. The invention also includes a pharmaceutical preparation of 16-HETE. Methods and products are also provided for treating thromboembolic stroke. The method involves the administration of 16-HETE in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke. Preferably, the 16-HETE is 16(R)-HETE and the thrombolytic agent is tPA. The product is a pharmaceutical preparation of 16- HETE and a thrombolytic agent and a pharmaceutically acceptable carrier.
La présente invention concerne des procédés et des produits pour inhiber l'adhésion ou l'agrégation de neutrohiles. L'invention décrit un traitement permettant d'inhiber chez un sujet l'adhésion ou l'agrégation de neutrophiles en administrant audit sujet un acide 16-hydroxyeicosatétraénoïque (16-HETE). 16-HETE est un métabolite d'acide arachidonique. L'invention décrit également une préparation pharmaceutique à base de 16-HETE. Elle décrit en outre des procédés et des produits pour le traitement d'attaques d'apoplexie thromboemboliques. Le procédé consiste à administrer 16-HETE combiné à un agent thrombolytique à un patient souffrant d'une attaque d'apoplexie thromboembolique. De préférence, 16-HETE est 16(R)-HETE et l'agent thrombolytique est tPA. Le produit est une préparation pharmaceutique obtenue à partir de 16-HETE associé à un agent thrombolytique et un excipient pharmaceutiquement acceptable.
Balazy Michael
Bednar Martin M.
Falck John R.
Gross Cordell E.
Board Of Regents The University Of Texas System
New York Medical College
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Vermont And State Agricultural College
LandOfFree
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