Novel arylheteroalkylamine derivatives

Details Novel arylheteroalkylamine derivatives Novel arylheteroalkylamine derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/62 (2006.01) A61K 31/13 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C07C 217/54 (2006.01) C07C 255/54 (2006.01) C07C 323/29 (2006.01) C07C 323/31 (2006.01) C07C 323/36 (2006.01) C07C 323/62 (2006.01) C07D 213/85 (2006.01) C07D 275/02 (2006.01) C07D 275/03 (2006.01) C07D 277/20 (2006.01) C07D 277/24 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2446120

There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

La présente invention concerne de nouveaux composés de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, T, U, X, Y, V et W sont tels que définis dans la spécification, et des sels de ces composés, acceptables d'un point de vue pharmaceutique, ainsi que des énantiomères et des composés racémiques de ceux-ci. L'invention a également pour objet des procédés permettant leur préparation, des compositions les contenant et leur utilisation dans le cadre d'une thérapie. Lesdits composés sont des inhibiteurs de la synthase d'oxyde nitrique et sont de ce fait particulièrement utiles dans le cadre du traitement ou de la prévention de maladies et douleurs inflammatoires.

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