Novel atisane compounds and use thereof

Details Novel atisane compounds and use thereof Novel atisane compounds and use thereof

C - Chemistry, Metallurgy

07

C

C07C 35/44 (2006.01) A61K 31/047 (2006.01) A61K 31/075 (2006.01) A61K 31/095 (2006.01) A61K 31/10 (2006.01) A61K 31/11 (2006.01) A61K 31/145 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/255 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/655 (2006.01) A61P 17/00 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 27/16 (2006.01) A61P 37/08 (2006.01) A61P 39/02 (2006.01)

Patent

CA 2443456

The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury caused by radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. (see formula I) Wherein Z represents a bivalent organic group and the like of from 2 to 3 carbon atom(s) which may have a substituent; and R3 represents a carboxyl group and the like.

La présente invention se rapporte à un nouveau composé qui s'avère très efficace pour améliorer les troubles cellulaires provoqués par des radicaux et pour inhiber la neurotoxicité induite par des neurotransmetteurs excitateurs tel que l'acide glutamique. Ce nouveau composé est représenté par la formule suivante et l'invention se rapporte également à un sel ou à un hydrate de ce composé. Dans la formule (I), Z représente un groupe organique C¿2-3? bivalent, éventuellement substitué, et analogue et R?3¿ représente un groupe carboxyle ou analogue.

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