Novel azabicyclic compounds and the use thereof

Details Novel azabicyclic compounds and the use thereof Novel azabicyclic compounds and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 9/10 (2006.01) A61K 9/12 (2006.01) A61K 31/416 (2006.01) A61K 31/4162 (2006.01) A61K 31/4188 (2006.01) A61K 31/4745 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61P 9/04 (2006.01) C07D 403/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2663297

The present application relates to compounds of the formula (I) which act as stimulators of soluble guanylate cyclase and to their use for treatment and/or prevention of heart failure, angina pectoris, hypertension, pulmonary hypertension, ischaemias, vascular disorders, thromboembolic disorders and arteriosclerosis. L-CH2-M-Q (I) in which L is phenyl, pyridyl, furyl, thienyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl or (C5-C7)-cycloalkyl, M is a bicyclic heteroaryl group of the formula (a-1), (b-1) or (c-1), in which the attachment site to the group is -CH2-L, the attachment site to the group is Q, and A, B, D and E are each CH, CR1 or N, where not more than two of the ring members A, B, D and E are the same, and Q is an unsaturated or aromatic 5- or 6-membered heterocycle having up to four heteroatoms from the group of N, O and/or S.

La présente invention concerne un composé de formule (I), qui agit en tant que stimulant de la guanylatcyclase soluble et son utilisation pour le traitement et/ou la prévention de l'insuffisance cardiaque, de l'angine de poitrine, de l'hypertonie, de l'hypertonie pulmonaire, de l'ischémie, des angiopathies, des maladies thromboemboliques et de l'artériosclérose. L-CH2-M-Q (I) dans laquelle L représente phényle, pyridyle, furyle, thiényle, thiazolyle, oxazolyle, isothiazolyle, isoxazolyle ou un cycloalkyle en (C5-C7), M représente un groupement hétéroaryle de formule (a-1), (b-1) ou (c-1), le site de liaison représentant le groupement -CH2-L, le site de liaison représentant le groupement Q, A, B, D et E représentant chacun CH, CR1 ou N. Selon l'invention, au plus deux des éléments cycliques A, B, D et E sont identiques et Q représente un hétérocycle insaturé ou aromatique ayant 5 ou 6 éléments, avec jusqu'à quatre hétéroatomes de la série N, O et/ou S.

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