C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/06 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2063938
The present invention provides certain novel azadecalin amides and thioamides of the formula (see formula I) wherein E is O or S; A is a saturated C1-C14 alkylene of straight or branched chain configuration; Y is oxygen, sulfur, sulfinyl or sulfonyl; B is a saturated C1-C14 alkylene of straight or branched chain configuration; and D is a C1-C4 saturated or unsaturated alkyl of straight or branched chain configuration, -CF3, -CHF2, -CH2F, or phenyl, which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in need thereof.
Moore William R.
Van Sickle William A.
Wannamaker Marion W.
Merrell Dow Pharmaceuticals Inc.
Merrell Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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