Novel azole derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 405/04 (2006.01) A61K 31/4178 (2006.01) A61K 31/4355 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07D 405/12 (2006.01) C07D 487/04 (2006.01) C07D 491/10 (2006.01) C07D 491/20 (2006.01)

Patent

CA 2507742

A compound represented by the following general formula (I): (I) wherein Az represents an optionally substituted group comprising a monocyclic azole group or a bicyclic aromatic ring group having two azoles, which may be either the same or different, fused together; T, U, V and W independently represent each an optionally substituted methyne group or a nitrogen atom wherein at least two of them represent the methyne groups; and X represents a nitrogen atom or a methyne group. The above compound is useful as an agent for treating various diseases in which NPY participates, for example, circulatory diseases, nervous diseases, metabolic diseases, genital diseases, digestive diseases, respiratory diseases, inflammatory diseases, glaucoma, etc.

L'invention concerne un composé représenté par la formule générale suivante (I): dans laquelle Az représente un groupe, éventuellement substitué, comprenant un groupe azole monocyclique ou un groupe bicyclique aromatique comprenant deux azoles, qui peuvent être les mêmes ou différents, fusionnés; T, U, V et W représentent indépendamment chacun un groupe méthyne, éventuellement substitué ou un atome d'azote, l'un d'entre eux au moins représentant les groupes méthyne; et X représente un atome d'azote ou un groupe méthyne. Le composé ci-dessus est utile comme agent pour traiter diverses maladies dans lesquelles participe NPY, entre autres, les maladies circulatoires, les maladies nerveuses, les maladies métaboliques, les maladies génitales, les maladies digestives, les maladies respiratoires, les maladies inflammatoires, le glaucome

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